7TMW
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Relaxin receptor 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short fusion | polymer | 984 | 113442.9 | 1 | UniProt (Q9HBX9) UniProt (P63092) Pfam (PF13855) Pfam (PF00001) Pfam (PF00503) Pfam (PF00057) In PDB | Homo sapiens (human) | Leucine-rich repeat-containing G-protein coupled receptor 7,Relaxin family peptide receptor 1, Adenylate cyclase-stimulating G alpha protein,Adenylate cyclase-stimulating G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | N | Camelid antibody VHH fragment Nb35 | polymer | 159 | 17444.3 | 1 | Lama glama (llama) |
Sequence modifications
R: 23 - 1000 (UniProt: Q9HBX9)
R: 1199 - 1379 (UniProt: P63092)
B: 12 - 350 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp 2 | - | expression tag |
Tyr 3 | - | expression tag |
Lys 4 | - | expression tag |
Asp 5 | - | expression tag |
Asp 6 | - | expression tag |
Asp 7 | - | expression tag |
Asp 8 | - | expression tag |
Gly 9 | - | expression tag |
Gly 10 | - | expression tag |
Ser 11 | - | expression tag |
Leu 12 | - | expression tag |
Glu 13 | - | expression tag |
Val 14 | - | expression tag |
Leu 15 | - | expression tag |
Phe 16 | - | expression tag |
Gln 17 | - | expression tag |
Gly 18 | - | expression tag |
Pro 19 | - | expression tag |
Gly 20 | - | expression tag |
Gly 21 | - | expression tag |
Ser 22 | - | expression tag |
Asn 1001 | - | linker |
Ser 1002 | - | linker |
Lys 1003 | - | linker |
Thr 1004 | - | linker |
Glu 1005 | - | linker |
Asp 1006 | - | linker |
Gln 1007 | - | linker |
Arg 1008 | - | linker |
Asn 1009 | - | linker |
Glu 1010 | - | linker |
Glu 1011 | - | linker |
Lys 1012 | - | linker |
Ala 1013 | - | linker |
Gln 1014 | - | linker |
Arg 1015 | - | linker |
Glu 1016 | - | linker |
Ala 1017 | - | linker |
Asn 1018 | - | linker |
Lys 1019 | - | linker |
Lys 1020 | - | linker |
Ile 1021 | - | linker |
Glu 1022 | - | linker |
Lys 1023 | - | linker |
Gln 1024 | - | linker |
Leu 1025 | - | linker |
Gln 1026 | - | linker |
Lys 1027 | - | linker |
Asp 1028 | - | linker |
Lys 1029 | - | linker |
Gln 1030 | - | linker |
Val 1031 | - | linker |
Tyr 1032 | - | linker |
Arg 1033 | - | linker |
Ala 1034 | - | linker |
Thr 1035 | - | linker |
His 1036 | - | linker |
Arg 1037 | - | linker |
Leu 1038 | - | linker |
Leu 1039 | - | linker |
Leu 1040 | - | linker |
Leu 1041 | - | linker |
Gly 1042 | - | linker |
Ala 1043 | - | linker |
Asp 1044 | - | linker |
Asn 1045 | - | linker |
Ser 1046 | - | linker |
Gly 1047 | - | linker |
Lys 1048 | - | linker |
Ser 1049 | - | linker |
Thr 1050 | - | linker |
Ile 1051 | - | linker |
Val 1052 | - | linker |
Lys 1053 | - | linker |
Gln 1054 | - | linker |
Met 1055 | - | linker |
Arg 1056 | - | linker |
Ile 1057 | - | linker |
Tyr 1058 | - | linker |
His 1190 | - | linker |
Gly 1191 | - | linker |
Gly 1192 | - | linker |
Ser 1193 | - | linker |
Gly 1194 | - | linker |
Gly 1195 | - | linker |
Ser 1196 | - | linker |
Gly 1197 | - | linker |
Gly 1198 | - | linker |
PDB | External Database | Details |
---|---|---|
Asp 1244 | Ala 249 | conflict |
Asp 1247 | Ser 252 | conflict |
- | Asn 254 | deletion |
- | Met 255 | deletion |
- | Val 256 | deletion |
- | Ile 257 | deletion |
- | Arg 258 | deletion |
- | Glu 259 | deletion |
- | Asp 260 | deletion |
- | Asn 261 | deletion |
- | Gln 262 | deletion |
- | Thr 263 | deletion |
Ala 1357 | Ile 372 | conflict |
Ile 1360 | Val 375 | conflict |
PDB | External Database | Details |
---|---|---|
Met 1 | - | expression tag |
His 2 | - | expression tag |
His 3 | - | expression tag |
His 4 | - | expression tag |
His 5 | - | expression tag |
His 6 | - | expression tag |
His 7 | - | expression tag |
Gly 8 | - | expression tag |
Ser 9 | - | expression tag |
Ser 10 | - | expression tag |
Gly 11 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 177282.4 | |
All* | Total formula weight | 177282.4 |