7SR8
Molecular mechanism of the the wake-promoting agent TAK-925
Summary for 7SR8
Entry DOI | 10.2210/pdb7sr8/pdb |
Related | 7SQO |
EMDB information | 25389 25399 |
Descriptor | a modified Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total) |
Functional Keywords | orexin, gpcr, narcolepsy, signaling protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 5 |
Total formula weight | 150380.19 |
Authors | Yin, J.,Chapman, K.,Lian, P.,De Brabander, J.K.,Rosenbaum, D.M. (deposition date: 2021-11-08, release date: 2022-06-08) |
Primary citation | Yin, J.,Kang, Y.,McGrath, A.P.,Chapman, K.,Sjodt, M.,Kimura, E.,Okabe, A.,Koike, T.,Miyanohana, Y.,Shimizu, Y.,Rallabandi, R.,Lian, P.,Bai, X.,Flinspach, M.,De Brabander, J.K.,Rosenbaum, D.M. Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13:2902-2902, 2022 Cited by PubMed: 35614071DOI: 10.1038/s41467-022-30601-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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