7SR8

Molecular mechanism of the the wake-promoting agent TAK-925

Summary for 7SR8

Entry DOI	10.2210/pdb7sr8/pdb
Related	7SQO
EMDB information	25389 25399
Descriptor	a modified Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	orexin, gpcr, narcolepsy, signaling protein
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	150380.19
Authors	Yin, J.,Chapman, K.,Lian, P.,De Brabander, J.K.,Rosenbaum, D.M. (deposition date: 2021-11-08, release date: 2022-06-08)
Primary citation	Yin, J.,Kang, Y.,McGrath, A.P.,Chapman, K.,Sjodt, M.,Kimura, E.,Okabe, A.,Koike, T.,Miyanohana, Y.,Shimizu, Y.,Rallabandi, R.,Lian, P.,Bai, X.,Flinspach, M.,De Brabander, J.K.,Rosenbaum, D.M. Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13:2902-2902, 2022 Cited by PubMed: 35614071 DOI: 10.1038/s41467-022-30601-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation