7SR8
Molecular mechanism of the the wake-promoting agent TAK-925
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | a modified Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 238 | 27638.5 | 1 | Homo sapiens | ||
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 82 | 9137.5 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | E | scFv16 | polymer | 259 | 27784.9 | 1 | Homo sapiens | ||
5 | R | Hypocretin receptor type 2 | polymer | 407 | 46848.0 | 1 | UniProt (Q548Y0) Pfam (PF03827) Pfam (PF00001) UniProt (by SIFTS) (O43614) In PDB | Homo sapiens (Human) | Orexin receptor type 2 |
6 | R | methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate | non-polymer | 424.6 | 1 | Chemie (A6F) | |||
7 | R | OLEIC ACID | non-polymer | 282.5 | 4 | Chemie (OLA) |
Sequence modifications
G: 2 - 71 (UniProt: P59768)
R: 3 - 408 (UniProt: Q548Y0)
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
Gly -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Gly 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 2 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 148825.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1554.4 | |
All* | Total formula weight | 150380.2 |