PDB: 902 件ウェブページステータス検索Chemie searchBIRD

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6KPG	Cryo-EM structure of CB1-G protein complex 分子名称: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hua, T, Li, X.T, Wu, L.J, Makriyannis, A, Wang, Y.X, Shen, L, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2020-03-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
6LI3	cryo-EM structure of GPR52-miniGs-NB35 分子名称: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Li, M, Wang, N, Xu, F, Wu, J, Lei, M. 登録日 2019-12-10 公開日 2020-02-26 最終更新日 2020-03-18 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
6OMM	Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. 登録日 2019-04-19 公開日 2020-02-26 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling. Nat Commun, 11, 2020
6M1I	CryoEM structure of human PAC1 receptor in complex with PACAP38 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6LPB	Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. 登録日 2020-01-09 公開日 2020-03-11 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
6M1H	CryoEM structure of human PAC1 receptor in complex with maxadilan 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. 登録日 2020-02-26 公開日 2020-03-11 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism. Cell Res., 30, 2020
6UUN	CryoEM Structure of the active Adrenomedullin 1 receptor G protein complex with adrenomedullin peptide 分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-10-30 公開日 2020-03-25 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6LMK	Cryo-EM structure of the human glucagon receptor in complex with Gs 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Tai, L, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6UUS	CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide 分子名称: ADM, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-10-31 公開日 2020-04-01 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (2.4 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6UVA	CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin 2 peptide 分子名称: Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Belousoff, M.J, Liang, Y.L, Sexton, P, Danev, R. 登録日 2019-11-01 公開日 2020-04-01 最終更新日 2020-04-29 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. Acs Pharmacol Transl Sci, 3, 2020
6LML	Cryo-EM structure of the human glucagon receptor in complex with Gi1 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6U7C	Human GRK2 in complex with Gbetagamma subunits and CCG258747 分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(2H-indazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2019-09-02 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97, 2020
6K41	cryo-EM structure of alpha2BAR-GoA complex 分子名称: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K. 登録日 2019-05-23 公開日 2020-04-15 最終更新日 2020-05-13 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16, 2020
6K42	cryo-EM structure of alpha2BAR-Gi1 complex 分子名称: 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K. 登録日 2019-05-23 公開日 2020-04-15 最終更新日 2020-05-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16, 2020
6WHC	CryoEM Structure of the glucagon receptor with a dual-agonist peptide 分子名称: Dual-agonist peptide, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Belousoff, M.J, Sexton, P, Danev, R. 登録日 2020-04-07 公開日 2020-05-27 最終更新日 2020-07-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide. J.Biol.Chem., 295, 2020
6VMS	Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane 分子名称: Endolysin,D(2) dopamine receptor,D(2) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yin, J, Chen, K.M, Clark, M.J, Hijazi, M, Kumari, P, Bai, X, Sunahara, R.K, Barth, P, Rosenbaum, D.M. 登録日 2020-01-28 公開日 2020-06-17 最終更新日 2020-08-19 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature, 584, 2020
6WWZ	Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein 分子名称: C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. 登録日 2020-05-09 公開日 2020-06-24 最終更新日 2020-07-01 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun, 11, 2020
6VCB	Cryo-EM structure of the Glucagon-like peptide-1 receptor in complex with G protein, GLP-1 peptide and a positive allosteric modulator 分子名称: 1-[(1R)-1-(2,6-dichloro-3-methoxyphenyl)ethyl]-6-{2-[(2R)-piperidin-2-yl]phenyl}-1H-benzimidazole, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... 著者 Sun, B, Feng, D, Bueno, A, Kobilka, B, Sloop, K. 登録日 2019-12-20 公開日 2020-07-22 最終更新日 2020-09-30 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural insights into probe-dependent positive allosterism of the GLP-1 receptor. Nat.Chem.Biol., 16, 2020
7BZ2	Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. 分子名称: Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. 登録日 2020-04-26 公開日 2020-08-05 実験手法 ELECTRON MICROSCOPY (3.82 Å) 主引用文献 Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
6WI9	Human secretin receptor Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Belousoff, M.J, Khoshouei, M. 登録日 2020-04-09 公開日 2020-08-12 最終更新日 2020-09-02 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
6WPW	GCGR-Gs signaling complex bound to a designed glucagon derivative 分子名称: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. 登録日 2020-04-28 公開日 2020-08-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369, 2020
6WZG	Human secretin receptor Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Piper, S.J, Belousoff, M.J, Danev, R. 登録日 2020-05-13 公開日 2020-08-12 最終更新日 2020-09-02 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Structure and dynamics of the active Gs-coupled human secretin receptor. Nat Commun, 11, 2020
7C2E	GLP-1R-Gs complex structure with a small molecule full agonist 分子名称: 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Ma, H, Yuan, D.P, Huang, W, Wenge, Z, Xu, E. 登録日 2020-05-07 公開日 2020-08-26 最終更新日 2020-12-16 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30, 2020
6LFM	Cryo-EM structure of a class A GPCR 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6LFO	Cryo-EM structure of a class A GPCR monomer 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020

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