7C2E

GLP-1R-Gs complex structure with a small molecule full agonist

Summary for 7C2E

Entry DOI	10.2210/pdb7c2e/pdb
EMDB information	30274
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, cryoem, glp-1, membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	164522.37
Authors	Ma, H.,Yuan, D.P.,Huang, W.,Wenge, Z.,Xu, E. (deposition date: 2020-05-07, release date: 2020-08-26, Last modification date: 2024-11-20)
Primary citation	Ma, H.,Huang, W.,Wang, X.,Zhao, L.,Jiang, Y.,Liu, F.,Guo, W.,Sun, X.,Zhong, W.,Yuan, D.,Xu, H.E. Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30:1140-1142, 2020 Cited by PubMed: 32724086 DOI: 10.1038/s41422-020-0384-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.2 Å)

Structure validation