7C2E
GLP-1R-Gs complex structure with a small molecule full agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 394 | 45683.4 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (N) | Nanobody 35|Lama glama | polymer | 138 | 15140.7 | 1 | Lama glama | ||
| 5 | E (R) | Glucagon-like peptide 1 receptor | polymer | 491 | 56748.4 | 1 | UniProt (P43220) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (Human) | GLP-1R |
| 6 | F (R) | 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid | non-polymer | 554.6 | 1 | Chemie (FFR) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 24 - 463 (UniProt: P43220)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| Lys -7 | - | expression tag |
| Thr -6 | - | expression tag |
| Ile -5 | - | expression tag |
| Ile -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Tyr 0 | - | expression tag |
| Ile 1 | - | expression tag |
| Phe 2 | - | expression tag |
| Cys 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Val 5 | - | expression tag |
| Phe 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Asp 8 | - | expression tag |
| Tyr 9 | - | expression tag |
| Lys 10 | - | expression tag |
| Asp 11 | - | expression tag |
| Asp 12 | - | expression tag |
| Asp 13 | - | expression tag |
| Asp 14 | - | expression tag |
| Leu 15 | - | expression tag |
| Glu 16 | - | expression tag |
| Val 17 | - | expression tag |
| Leu 18 | - | expression tag |
| Phe 19 | - | expression tag |
| Gln 20 | - | expression tag |
| Gly 21 | - | expression tag |
| Pro 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Phe 260 | Leu 260 | conflict |
| Pro 464 | - | expression tag |
| Ala 465 | - | expression tag |
| Gly 466 | - | expression tag |
| Leu 467 | - | expression tag |
| Glu 468 | - | expression tag |
| Val 469 | - | expression tag |
| Leu 470 | - | expression tag |
| Phe 471 | - | expression tag |
| Gln 472 | - | expression tag |
| Gly 473 | - | expression tag |
| Pro 474 | - | expression tag |
| His 475 | - | expression tag |
| His 476 | - | expression tag |
| His 477 | - | expression tag |
| His 478 | - | expression tag |
| His 479 | - | expression tag |
| His 480 | - | expression tag |
| His 481 | - | expression tag |
| His 482 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 163967.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 554.6 | |
| All* | Total formula weight | 164522.4 |
