6K41

cryo-EM structure of alpha2BAR-GoA complex

Summary for 6K41

Entry DOI	10.2210/pdb6k41/pdb
EMDB information	9911 9912
Descriptor	Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, complex, cryo-em, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	177619.78
Authors	Yuan, D.,Liu, Z.,Wang, H.W.,Kobilka, B.K. (deposition date: 2019-05-23, release date: 2020-04-15, Last modification date: 2020-05-13)
Primary citation	Yuan, D.,Liu, Z.,Kaindl, J.,Maeda, S.,Zhao, J.,Sun, X.,Xu, J.,Gmeiner, P.,Wang, H.W.,Kobilka, B.K. Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16:507-512, 2020 Cited by PubMed: 32152538 DOI: 10.1038/s41589-020-0492-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation