6WPW
GCGR-Gs signaling complex bound to a designed glucagon derivative
Summary for 6WPW
Entry DOI | 10.2210/pdb6wpw/pdb |
EMDB information | 21866 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | gpcr, g protein, glucagon, signaling, complex, signaling protein-hormone-immune system complex, signaling protein/hormone/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 166540.70 |
Authors | Hilger, D.,Krishna Kumar, K.,Hu, H.,Mathiesen, J.M.,Skiniotis, G.,Kobilka, B.K. (deposition date: 2020-04-28, release date: 2020-08-12) |
Primary citation | Hilger, D.,Kumar, K.K.,Hu, H.,Pedersen, M.F.,O'Brien, E.S.,Giehm, L.,Jennings, C.,Eskici, G.,Inoue, A.,Lerch, M.,Mathiesen, J.M.,Skiniotis, G.,Kobilka, B.K. Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369:-, 2020 Cited by PubMed: 32732395DOI: 10.1126/science.aba3373 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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