6UUS

CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide

Summary for 6UUS

• Entry DOI: 10.2210/pdb6uus/pdb
• EMDB information: 20901
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, adrenomedullin 2 receptor complex, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 186429.36

Authors

Belousoff, M.J.,Liang, Y.L.,Sexton, P.,Danev, R. (deposition date: 2019-10-31, release date: 2020-04-01, Last modification date: 2020-04-29)

• Primary citation: Liang, Y.L.,Belousoff, M.J.,Fletcher, M.M.,Zhang, X.,Khoshouei, M.,Deganutti, G.,Koole, C.,Furness, S.G.B.,Miller, L.J.,Hay, D.L.,Christopoulos, A.,Reynolds, C.A.,Danev, R.,Wootten, D.,Sexton, P.M.; Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.; Acs Pharmacol Transl Sci, 3:263-284, 2020; PubMed: 32296767; DOI: 10.1021/acsptsci.9b00080

Experimental method

ELECTRON MICROSCOPY (2.4 Å)