6U7C
Human GRK2 in complex with Gbetagamma subunits and CCG258747
Summary for 6U7C
Entry DOI | 10.2210/pdb6u7c/pdb |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | g-protein coupled receptor kinase, kinase inhibitor, signaling protein, transferase-signaling protein complex, transferase/signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 125481.49 |
Authors | Bouley, R.,Tesmer, J.J.G. (deposition date: 2019-09-02, release date: 2020-04-15, Last modification date: 2023-10-11) |
Primary citation | Bouley, R.A.,Weinberg, Z.Y.,Waldschmidt, H.V.,Yen, Y.C.,Larsen, S.D.,Puthenveedu, M.A.,Tesmer, J.J.G. A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of themu-Opioid Receptor. Mol.Pharmacol., 97:392-401, 2020 Cited by PubMed: 32234810DOI: 10.1124/mol.119.118661 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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