6LPB

Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein

Summary for 6LPB

• Entry DOI: 10.2210/pdb6lpb/pdb
• EMDB information: 0940
• Descriptor: Pituitary adenylate cyclase-activating polypeptide, Pituitary adenylate cyclase-activating polypeptide type I receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: class b gpcr, pacap, pac1r, signaling protein-hormone complex, signaling protein/hormone
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 141495.37

Authors

Kobayashi, K.,Shihoya, W.,Nishizawa, T.,Nureki, O. (deposition date: 2020-01-09, release date: 2020-03-11, Last modification date: 2020-03-25)

• Primary citation: Kobayashi, K.,Shihoya, W.,Nishizawa, T.,Kadji, F.M.N.,Aoki, J.,Inoue, A.,Nureki, O.; Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.; Nat.Struct.Mol.Biol., 27:274-280, 2020; PubMed: 32157248; DOI: 10.1038/s41594-020-0386-8

Experimental method

ELECTRON MICROSCOPY (3.9 Å)