PDB: 282 件ウェブページステータス検索Chemie searchBIRD

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8HGO	The EGF-bound EGFR/HER2 ectodomain complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor, ... 著者 Zhang, Z, Bai, X. 登録日 2022-11-15 公開日 2023-02-08 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (3.31 Å) 主引用文献 Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
8HGS	The EGF-bound EGFR ectodomain homodimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Pro-epidermal growth factor, ... 著者 Zhang, Z, Bai, X. 登録日 2022-11-15 公開日 2023-02-15 最終更新日 2023-03-01 実験手法 ELECTRON MICROSCOPY (3.81 Å) 主引用文献 Structure and dynamics of the EGFR/HER2 heterodimer. Cell Discov, 9, 2023
8U4I	Structure of the HER4/NRG1b Homodimer Extracellular Domain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... 著者 Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. 登録日 2023-09-10 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain To Be Published
6OFY	Crystal Structure of Arachidonic Acid bound to V349I murine COX-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ARACHIDONIC ACID, ... 著者 Malkowski, M.G. 登録日 2019-04-01 公開日 2020-02-05 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex. Biochemistry, 58, 2019
8CN9	Factor VII binding Fab of the bispecific antibody HMB-001 in complex with Factor VII 分子名称: CALCIUM ION, CESIUM ION, Coagulation factor VII, ... 著者 Schluckebier, G, Johansson, E. 登録日 2023-02-22 公開日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders Nat Cardiovasc Res, 2023
8EOK	Structure of the C3bB proconvertase in complex with lufaxin and factor Xa 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ... 著者 Andersen, J.F, Lei, H. 登録日 2022-10-03 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
1F0S	Crystal Structure of Human Coagulation Factor XA Complexed with RPR208707 分子名称: CALCIUM ION, COAGULATION FACTOR XA, THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE 著者 Maignan, S, Guilloteau, J.P, Pouzieux, S, Choi-Sledeski, Y.M, Becker, M.R, Klein, S.I, Ewing, W.R, Pauls, H.W, Spada, A.P, Mikol, V. 登録日 2000-05-17 公開日 2000-09-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of human factor Xa complexed with potent inhibitors. J.Med.Chem., 43, 2000
3ENS	Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, Activated factor Xa heavy chain, ... 著者 Klei, H.E. 登録日 2008-09-25 公開日 2008-12-30 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design, Structure-Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors. J.Med.Chem., 51, 2008
1TOZ	NMR structure of the human NOTCH-1 ligand binding region 分子名称: Neurogenic locus notch homolog protein 1 著者 Hambleton, S, Valeyev, N.Y, Muranyi, A, Knott, V, Werner, J.M, Mcmichael, A.J, Handford, P.A, Downing, A.K. 登録日 2004-06-15 公開日 2004-10-12 最終更新日 2021-11-10 実験手法 SOLUTION NMR 主引用文献 Structural and functional properties of the human notch-1 ligand binding region STRUCTURE, 12, 2004
7SZ0	Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation 分子名称: Epidermal growth factor, Epidermal growth factor receptor 著者 Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. 登録日 2021-11-25 公開日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
7SZ1	Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation 分子名称: Epidermal growth factor, Epidermal growth factor receptor 著者 Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. 登録日 2021-11-25 公開日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
7SYD	Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation 分子名称: Epidermal growth factor, Epidermal growth factor receptor 著者 Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. 登録日 2021-11-24 公開日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
7SYE	Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation 分子名称: Epidermal growth factor, Epidermal growth factor receptor 著者 Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. 登録日 2021-11-24 公開日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
3ELA	Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor 分子名称: CALCIUM ION, Coagulation factor VIIA heavy chain, Coagulation factor VIIA light chain, ... 著者 Bjelke, J.R, Fodje, M, Svensson, L.A. 登録日 2008-09-21 公開日 2008-11-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity J.Biol.Chem., 283, 2008
1TPG	F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE) 分子名称: T-PLASMINOGEN ACTIVATOR F1-G 著者 Smith, B.O, Downing, A.K, Driscoll, P.C, Dudgeon, T.J, Campbell, I.D. 登録日 1995-06-14 公開日 1995-09-15 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator. Structure, 3, 1995
3CFW	L-selectin lectin and EGF domains 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, L-selectin, ... 著者 Mehta, P, Oganesyan, V, Terzyan, S, Mather, T, McEver, R.P. 登録日 2008-03-04 公開日 2008-03-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J.Biol.Chem., 292, 2017
7YB9	Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with L-2-hydroxyglutarate and factor X-derived peptide (39mer-4Ser) 分子名称: (2S)-2-HYDROXYPENTANEDIOIC ACID, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2022-06-29 公開日 2023-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with L-2-hydroxyglutarate and factor X-derived peptide (39mer-4Ser) To Be Published
7YBC	Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with (S)-4-hydroxy-4-methyl-2-oxoglutarate and factor X-derived peptide (39mer-4Ser) 分子名称: (2~{S})-2-methyl-2-oxidanyl-4-oxidanylidene-pentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2022-06-29 公開日 2023-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with (S)-4-hydroxy-4-methyl-2-oxoglutarate and factor X-derived peptide (39mer-4Ser) To Be Published
7YBB	Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with D-4-hydroxy-2-oxoglutarate and factor X-derived peptide (39mer-4Ser) 分子名称: (2~{R})-2-oxidanyl-4-oxidanylidene-pentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2022-06-29 公開日 2023-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with D-4-hydroxy-2-oxoglutarate and factor X-derived peptide (39mer-4Ser) To Be Published
7YB8	Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with D-2-hydroxyglutarate and factor X-derived peptide (39mer-4Ser) 分子名称: (2R)-2-hydroxypentanedioic acid, Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, ... 著者 Nakashima, Y, Brewitz, L, Schofield, C.J. 登録日 2022-06-29 公開日 2023-07-05 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with D-2-hydroxyglutarate and factor X-derived peptide (39mer-4Ser) To Be Published
1W2K	tf7a_4380 complex 分子名称: (2R)-2-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO)-N-BENZYL-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE, BLOOD COAGULATION FACTOR VIIA, CACODYLATE ION, ... 著者 Banner, D.W, D'Arcy, A, Groebke-Zbinden, K, Ackermann, J, Kirchhofer, D, Ji, Y.-H, Tschopp, T.B, Wallbaum, S, Weber, L. 登録日 2004-07-06 公開日 2005-06-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
1W0Y	tf7a_3771 complex 分子名称: 4-(4-BENZYLOXY-2-METHANESULFONYLAMINO-5-METHOXY-BENZYLAMINO)-BENZAMIDINE, BLOOD COAGULATION FACTOR VIIA, CACODYLATE ION, ... 著者 Banner, D.W, D'Arcy, A, Groebke-Zbinden, K, Ackermann, J, Kirchhofer, D, Ji, Y.-H, Tschopp, T.B, Wallbaum, S, Weber, L. 登録日 2004-05-27 公開日 2005-01-21 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
5UB5	human POGLUT1 in complex with human Notch1 EGF12 S458T mutant and UDP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Neurogenic locus notch homolog protein 1, ... 著者 Li, Z, Rini, J.M. 登録日 2016-12-20 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.089 Å) 主引用文献 Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1). Nat Commun, 8, 2017
5UK5	Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Garcia, K.C, Luca, V.C. 登録日 2017-01-19 公開日 2017-03-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science, 355, 2017
5VC1	Crystal structure of L-selectin lectin/EGF domains 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Wedepohl, S, Dernedde, J, Vahedi-Faridi, A, Tauber, R, Saenger, W, Bulut, H. 登録日 2017-03-30 公開日 2017-06-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 angstrom Resolution. Chembiochem, 18, 2017

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