5F85

Crystal structure of Drosophila Poglut1 (Rumi) complexed with its substrate protein (EGF repeat) and UDP

Summary for 5F85

• Entry DOI: 10.2210/pdb5f85/pdb
• Related: 5F84 5F86 5F87
• Descriptor: O-glucosyltransferase rumi, Coagulation factor IX, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: glycosyltransferase, protein o-glucosyltransferase, notch regulation, egf repeat, transferase-hydrolase complex, transferase/hydrolase
• Biological source: Drosophila melanogaster (Fruit fly); More
• Cellular location: Endoplasmic reticulum lumen : Q8T045; Secreted : P00740
• Total number of polymer chains: 2
• Total formula weight: 53506.97

Authors

Yu, H.J.,Li, H.L. (deposition date: 2015-12-09, release date: 2016-07-20, Last modification date: 2018-04-18)

• Primary citation: Yu, H.,Takeuchi, H.,Takeuchi, M.,Liu, Q.,Kantharia, J.,Haltiwanger, R.S.,Li, H.; Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations.; Nat. Chem. Biol., 12:735-740, 2016; PubMed: 27428513; DOI: 10.1038/nchembio.2135

Experimental method

X-RAY DIFFRACTION (2.15 Å)