3TZI
X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of G533V murine COX-2
Summary for 3TZI
Entry DOI | 10.2210/pdb3tzi/pdb |
Related | 1CVU 1DIY 3HS5 3KRK 3MDL 3QH0 |
Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | oxidoreductase, n-glycosylation, monotopic membrane protein |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 2 |
Total formula weight | 141404.57 |
Authors | Vecchio, A.J.,Malkowski, M.G. (deposition date: 2011-09-27, release date: 2012-04-25, Last modification date: 2023-09-13) |
Primary citation | Vecchio, A.J.,Orlando, B.J.,Nandagiri, R.,Malkowski, M.G. Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE. J.Biol.Chem., 287:24619-24630, 2012 Cited by PubMed: 22637474DOI: 10.1074/jbc.M112.372243 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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