3MDL

X-ray crystal structure of 1-arachidonoyl glycerol bound to the cyclooxygenase channel of cyclooxygenase-2

Summary for 3MDL

Entry DOI	10.2210/pdb3mdl/pdb
Related	1CVU 1DIY 3HS5 3HS6 3HS7 3KRK
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	cox-2, cyclooxygenase-2, endocannabinoid, oxidoreductase
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	140147.05
Authors	Vecchio, A.J.,Malkowski, M.G. (deposition date: 2010-03-30, release date: 2011-04-13, Last modification date: 2023-09-06)
Primary citation	Vecchio, A.J.,Malkowski, M.G. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J.Biol.Chem., 286:20736-20745, 2011 Cited by PubMed: 21489986 DOI: 10.1074/jbc.M111.230367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation