1CVU

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

Summary for 1CVU

Related6COX 5COX 1CQE 1LOX
DescriptorPROSTAGLANDIN H2 SYNTHASE-2, PROTEIN (9-MER), N-ACETYL-D-GLUCOSAMINE, ... (7 entities in total)
Functional Keywordscox-2, cyclooxygenase, prostaglandin, arachidonate, endoperoxide, oxidoreductase-peptide complex, oxidoreductase/peptide
Biological sourceMus musculus (house mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein Q05769
Total number of polymer chains3
Total molecular weight132743.2
Authors
Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G. (deposition date: 1999-08-24, release date: 2000-05-16, Last modification date: 2011-07-13)
Primary citation
Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Hood, W.F.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G.
Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405:97-101, 2000
PubMed: 10811226 (PDB entries with the same primary citation)
DOI: 10.1038/35011103
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.231170.7%9.9%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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