1CVU
CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROSTAGLANDIN H2 SYNTHASE-2 | polymer | 552 | 63416.4 | 2 | UniProt (Q05769) Pfam (PF00008) Pfam (PF03098) In PDB | Mus musculus (house mouse) | |
| 2 | F | PROTEIN (9-MER) | polymer | 9 | 907.0 | 1 | |||
| 3 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, G | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G04854NQ) | |||
| 5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | A, B | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 5 | Chemie (BOG) | |||
| 7 | A, B | ARACHIDONIC ACID | non-polymer | 304.5 | 2 | Chemie (ACD) | |||
| 8 | water | water | 18.0 | 771 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 583 (UniProt: Q05769)
| PDB | External Database | Details |
|---|---|---|
| Gln 310 | Asn 296 | engineered mutation |
| Lys 333 | Arg 319 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 127739.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2346.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2513.2 | |
| All* | Total formula weight | 132599.1 |
