6EYJ

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic ligand NV354

Summary for 6EYJ
DescriptorE-selectin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2~{S})-3-cyclohexyl-2-[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-3,5-bis(oxidanyl)-6-[(1~{R},2~{R})-2-[(2~{R},3~{S},4~{R},5~{S},6~{R})-3,4,5-tris(oxidanyl)-6-(trifluoromethyl)oxan-2-yl]oxycyclohexyl]oxy-oxan-4-yl]oxy-propanoic acid, ... (5 entities in total)
Functional Keywordscell adhesion, cell-adhesion molecule, c-type lectin, inflammation, leukocyte, glycomimetic, catch-bond
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight67053.82
Authors
Jakob, R.P.,Zihlmann, P.,Preston, R.C.,Varga, N.,Ernst, B.,Maier, T. (deposition date: 2017-11-13, release date: 2018-11-21, Last modification date: 2020-07-29)
Primary citationErnst, B.,Jakob, R.P.,Maier, T.,Preston, R.C.,Varga, N.,Zihlmann, P.
E-selectin lectin with different glycomimetic ligands
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
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PDB entries from 2021-06-16