6EYK
E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic ligand NV355
Summary for 6EYK
Entry DOI | 10.2210/pdb6eyk/pdb |
Descriptor | E-selectin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2~{S})-3-cyclohexyl-2-[(2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-[(1~{R},2~{R},3~{S})-3-methyl-2-[(2~{R},3~{S},4~{R},5~{S},6~{R})-3,4,5-tris(oxidanyl)-6-(trifluoromethyl)oxan-2-yl]oxy-cyclohexyl]oxy-3,5-bis(oxidanyl)oxan-4-yl]oxy-propanoic acid, ... (5 entities in total) |
Functional Keywords | cell adhesion, cell-adhesion molecule, c-type lectin, inflammation, leukocyte, glycomimetic, catch-bond |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33581.02 |
Authors | Jakob, R.P.,Zihlmann, P.,Preston, R.C.,Varga, N.,Ernst, B.,Maier, T. (deposition date: 2017-11-13, release date: 2018-11-21, Last modification date: 2024-01-17) |
Primary citation | Varga, N.,Zihlmann, P.,Preston, R.C.,Jakob, R.P.,Maier, T.,Ernst, B. E-selectin lectin with different glycomimetic ligands To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
Download full validation report