6YYY

Aspartyl/Asparaginyl beta-hydroxylase (AspH) oxygenase and TPR domains in complex with manganese, 4,4-dimethyl-2-oxoglutarate, and factor X substrate peptide fragment(39mer-4Ser)

Summary for 6YYY

Entry DOI	10.2210/pdb6yyy/pdb
Descriptor	Aspartyl/asparaginyl beta-hydroxylase, Coagulation factor X, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	aspartyl/asparaginyl beta-hydroxylase, dioxygenase, oxidoreductase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	53824.81
Authors	Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2020-05-06, release date: 2021-03-17, Last modification date: 2024-02-07)
Primary citation	Brewitz, L.,Nakashima, Y.,Schofield, C.J. Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase. Chem Sci, 12:1327-1342, 2020 Cited by PubMed: 34163896 DOI: 10.1039/d0sc04301j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation