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3SW2

X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide

Summary for 3SW2
Entry DOI10.2210/pdb3sw2/pdb
Related3ENS 3HPT 3K9X
DescriptorCoagulation factor X, 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide, SODIUM ION, ... (7 entities in total)
Functional Keywordsserine protease, epidermal growth factor-like domain, blood coagulation factor, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, hydrolase, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P00742 P00742
Total number of polymer chains2
Total formula weight37809.20
Authors
Klei, H.E. (deposition date: 2011-07-13, release date: 2011-11-16, Last modification date: 2023-09-13)
Primary citationShi, Y.,O'Connor, S.P.,Sitkoff, D.,Zhang, J.,Shi, M.,Bisaha, S.N.,Wang, Y.,Li, C.,Ruan, Z.,Michael Lawrence, R.,Klei, H.E.,Kish, K.,Liu, E.C.,Seiler, S.M.,Schweizer, L.,Steinbacher, T.E.,Schumacher, W.A.,Robl, J.A.,Macor, J.E.,Atwal, K.S.,Stein, P.D.
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 21:7516-7521, 2011
Cited by
PubMed: 22041058
DOI: 10.1016/j.bmcl.2011.06.098
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.42 Å)
Structure validation

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