5W58

Crystal Complex of Cyclooxygenase-2: (S)-ARN-2508 (a dual COX and FAAH inhibitor)

Summary for 5W58

Entry DOI	10.2210/pdb5w58/pdb
Related PRD ID	PRD_900017
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	cyclooxygenase, protein-inhibitor complex, prostaglandin, faah-cox dual inhibition, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	69991.39
Authors	Xu, S.,Goodman, M.C.,Banerjee, S.,Piomelli, D.,Marnett, L.J. (deposition date: 2017-06-14, release date: 2018-01-31, Last modification date: 2023-10-04)
Primary citation	Goodman, M.C.,Xu, S.,Rouzer, C.A.,Banerjee, S.,Ghebreselasie, K.,Migliore, M.,Piomelli, D.,Marnett, L.J. Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J. Biol. Chem., 293:3028-3038, 2018 Cited by PubMed: 29326169 DOI: 10.1074/jbc.M117.802058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.267 Å)

Structure validation