7SYE

Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation

Summary for 7SYE

Entry DOI	10.2210/pdb7sye/pdb
EMDB information	25522 25523
Descriptor	Epidermal growth factor receptor, Epidermal growth factor (2 entities in total)
Functional Keywords	receptor tyrosine kinases, epidermal growth factor receptor, signaling protein, signaling protein-receptor complex, signaling protein/receptor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	281324.71
Authors	Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. (deposition date: 2021-11-24, release date: 2021-12-22)
Primary citation	Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10:-, 2021 Cited by PubMed: 34846302 DOI: 10.7554/eLife.73218 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation