7SYE

Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Epidermal growth factor receptor	polymer	1210	134433.3	2	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) Pfam (PF21314) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2	C, D	Epidermal growth factor	polymer	53	6229.0	2	UniProt (P01133) Pfam (PF00008) In PDB	Homo sapiens (human)	Urogastrone

Sequence modifications

A, B: -23 - 1186 (UniProt: P00533)

PDB	External Database	Details
Asn 232	Asp 256	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	281324.7
All*	Total formula weight	281324.7

*Water molecules are not included.