5FMA

human Notch 1, EGF 4-7

Summary for 5FMA

Entry DOI	10.2210/pdb5fma/pdb
Related	5FM9
Descriptor	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	transcription, transmembrane, developmental, protein, notch signaling pathway, differentiation, phosphorylation, egf- like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, egf, notch, jagged, membrane
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531
Total number of polymer chains	2
Total formula weight	33161.63
Authors	Weisshuhn, P.C.,Sheppard, D.,Taylor, P.,Whiteman, P.,Lea, S.M.,Handford, P.A.,Redfield, C. (deposition date: 2015-11-02, release date: 2016-04-13, Last modification date: 2024-01-10)
Primary citation	Weisshuhn, P.C.,Sheppard, D.,Taylor, P.,Whiteman, P.,Lea, S.M.,Handford, P.A.,Redfield, C. Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies. Structure, 24:555-, 2016 Cited by PubMed: 26996961 DOI: 10.1016/J.STR.2016.02.010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation