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7X9B
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Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Tang, T, Han, S, Zhao, Q, Wu, B.
登録日2022-03-15
公開日2022-05-18
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
7X9C
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Cryo-EM structure of neuropeptide Y Y4 receptor in complex with PP and Gi
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Tang, T, Han, S, Zhao, Q, Wu, B.
登録日2022-03-15
公開日2022-05-18
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
7X9A
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Cryo-EM structure of neuropeptide Y Y1 receptor in complex with NPY and Gi
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Tang, T, Han, S, Zhao, Q, Wu, B.
登録日2022-03-15
公開日2022-05-18
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
7V68
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An Agonist and PAM-bound Class A GPCR with Gi protein complex structure
分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, J.J, Wu, L.J, Wu, M, Hua, T, Liu, Z.J, Wang, T.
登録日2021-08-20
公開日2022-05-11
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
7V6A
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Cry-EM structure of M4-c110-G protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T.
登録日2021-08-20
公開日2022-05-11
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
7V69
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Cryo-EM structure of a class A GPCR-G protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, J.J, Wu, M, Wu, L.J, Hua, T, Liu, Z.J, Wang, T.
登録日2021-08-20
公開日2022-05-11
最終更新日2022-11-23
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.
Nat Commun, 13, 2022
7XJH
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BU of 7xjh by Molmil
Isoproterenol-activated dog beta3 adrenergic receptor
分子名称: Beta-3 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Shihoya, W, Nureki, O.
登録日2022-04-18
公開日2022-05-04
最終更新日2022-08-10
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structure of the beta 3-adrenergic receptor reveals the molecular basis of subtype selectivity.
Mol.Cell, 81, 2021
7XJI
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Solabegron-activated dog beta3 adrenergic receptor
分子名称: 3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid, Beta-3 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Shihoya, W, Nureki, O.
登録日2022-04-18
公開日2022-05-04
最終更新日2022-06-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures of the beta 3 adrenergic receptor bound to solabegron and isoproterenol.
Biochem.Biophys.Res.Commun., 611, 2022
7U2L
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BU of 7u2l by Molmil
C5guano-uOR-Gi-scFv16
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Wang, H, Qu, Q, Skiniotis, G, Kobilka, B.
登録日2022-02-24
公開日2022-05-04
最終更新日2023-02-08
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure-based design of bitopic ligands for the μ-opioid receptor.
Nature, 613, 2023
7SBF
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BU of 7sbf by Molmil
PZM21 bound Mu Opioid Receptor-Gi Protein Complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Huang, W, Qu, Q, Wang, H, Skiniotis, G, Kobilka, B.
登録日2021-09-24
公開日2022-04-20
最終更新日2022-07-06
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists.
Angew.Chem.Int.Ed.Engl., 61, 2022
7SCG
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BU of 7scg by Molmil
FH210 bound Mu Opioid Receptor-Gi Protein Complex
分子名称: (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wang, H, Kobilka, B.
登録日2021-09-28
公開日2022-04-20
最終更新日2022-07-06
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists.
Angew.Chem.Int.Ed.Engl., 61, 2022
7WQ4
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BU of 7wq4 by Molmil
Galanin-bound galanin receptor 2 in complex with Gq
分子名称: CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ...
著者Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
登録日2022-01-24
公開日2022-04-20
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
7W57
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Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者You, C, Xu, H.E, Jiang, Y.
登録日2021-11-29
公開日2022-04-20
最終更新日2022-06-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
7W55
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BU of 7w55 by Molmil
Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者You, C, Xu, H.E, Jiang, Y.
登録日2021-11-29
公開日2022-04-20
最終更新日2022-06-15
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
7W53
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Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者You, C, Xu, H.E, Jiang, Y.
登録日2021-11-29
公開日2022-04-20
最終更新日2022-06-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
7W56
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BU of 7w56 by Molmil
Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者You, C, Xu, H.E, Jiang, Y.
登録日2021-11-29
公開日2022-04-20
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Nat Commun, 13, 2022
7WQ3
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BU of 7wq3 by Molmil
Galanin-bound galanin receptor 1 in complex with Gi
分子名称: CHOLESTEROL, Galanin, Galanin receptor type 1, ...
著者Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
登録日2022-01-24
公開日2022-04-20
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
7WVX
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BU of 7wvx by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVW
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BU of 7wvw by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2
分子名称: FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVV
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Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2
分子名称: FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVY
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BU of 7wvy by Molmil
Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2
分子名称: Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7WVU
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BU of 7wvu by Molmil
Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1
分子名称: FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B.
登録日2022-02-11
公開日2022-04-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
7TUZ
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Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein
分子名称: (2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol, G-protein coupled receptor 183, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Chen, H, Hung, W, Li, X.
登録日2022-02-03
公開日2022-04-13
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
7TUY
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Cryo-EM structure of GSK682753A-bound EBI2/GPR183
分子名称: 8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, G-protein coupled receptor 183,Soluble cytochrome b562 fusion, anti-BRIL Fab Heavy chain, ...
著者Chen, H, Huang, W, Li, X.
登録日2022-02-03
公開日2022-04-13
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Structure, 30, 2022
7EJ0
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Structure of the alpha2A-adrenergic receptor GoA signaling complex
分子名称: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, J, Cao, S, Liu, Z, Du, Y.
登録日2021-04-01
公開日2022-04-13
最終更新日2022-10-26
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into ligand recognition, activation, and signaling of the alpha 2A adrenergic receptor.
Sci Adv, 8, 2022

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件を2024-06-12に公開中

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