7WV9

Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi protein

Summary for 7WV9

Entry DOI	10.2210/pdb7wv9/pdb
EMDB information	32850
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	complex, agonist, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	170389.00
Authors	Xu, Z.,Shao, Z. (deposition date: 2022-02-10, release date: 2022-06-15, Last modification date: 2024-04-03)
Primary citation	Yang, X.,Wang, X.,Xu, Z.,Wu, C.,Zhou, Y.,Wang, Y.,Lin, G.,Li, K.,Wu, M.,Xia, A.,Liu, J.,Cheng, L.,Zou, J.,Yan, W.,Shao, Z.,Yang, S. Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nat.Chem.Biol., 18:831-840, 2022 Cited by PubMed: 35637350 DOI: 10.1038/s41589-022-01038-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.36 Å)

Structure validation