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7WV9

Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0001973biological_processG protein-coupled adenosine receptor signaling pathway
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0007194biological_processnegative regulation of adenylate cyclase activity
A0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
A0007214biological_processgamma-aminobutyric acid signaling pathway
A0007584biological_processresponse to nutrient
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0032930biological_processpositive regulation of superoxide anion generation
A0035810biological_processpositive regulation of urine volume
A0044297cellular_componentcell body
A0045202cellular_componentsynapse
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046628biological_processpositive regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0050805biological_processnegative regulation of synaptic transmission
A0051301biological_processcell division
A0051924biological_processregulation of calcium ion transport
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0098992cellular_componentneuronal dense core vesicle
A0140199biological_processnegative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
A1903561cellular_componentextracellular vesicle
A1904707biological_processpositive regulation of vascular associated smooth muscle cell proliferation
A2000179biological_processpositive regulation of neural precursor cell proliferation
A2001234biological_processnegative regulation of apoptotic signaling pathway
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0005515molecular_functionprotein binding
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0016020cellular_componentmembrane
C0031681molecular_functionG-protein beta-subunit binding
C0048144biological_processfibroblast proliferation
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
R0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0004949molecular_functioncannabinoid receptor activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005739cellular_componentmitochondrion
R0005741cellular_componentmitochondrial outer membrane
R0005886cellular_componentplasma membrane
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007283biological_processspermatogenesis
R0007413biological_processaxonal fasciculation
R0007584biological_processresponse to nutrient
R0007611biological_processlearning or memory
R0007613biological_processmemory
R0010976biological_processpositive regulation of neuron projection development
R0014063biological_processnegative regulation of serotonin secretion
R0015629cellular_componentactin cytoskeleton
R0016020cellular_componentmembrane
R0019216biological_processregulation of lipid metabolic process
R0019222biological_processregulation of metabolic process
R0030424cellular_componentaxon
R0030426cellular_componentgrowth cone
R0031622biological_processpositive regulation of fever generation
R0031999biological_processnegative regulation of fatty acid beta-oxidation
R0032228biological_processregulation of synaptic transmission, GABAergic
R0032496biological_processresponse to lipopolysaccharide
R0033004biological_processnegative regulation of mast cell activation
R0033602biological_processnegative regulation of dopamine secretion
R0035094biological_processresponse to nicotine
R0038171biological_processcannabinoid signaling pathway
R0042220biological_processresponse to cocaine
R0042593biological_processglucose homeostasis
R0042734cellular_componentpresynaptic membrane
R0042802molecular_functionidentical protein binding
R0042995cellular_componentcell projection
R0043065biological_processpositive regulation of apoptotic process
R0043271biological_processnegative regulation of monoatomic ion transport
R0045121cellular_componentmembrane raft
R0045202cellular_componentsynapse
R0045471biological_processresponse to ethanol
R0045759biological_processnegative regulation of action potential
R0045776biological_processnegative regulation of blood pressure
R0045777biological_processpositive regulation of blood pressure
R0050796biological_processregulation of insulin secretion
R0051966biological_processregulation of synaptic transmission, glutamatergic
R0060135biological_processmaternal process involved in female pregnancy
R0060259biological_processregulation of feeding behavior
R0060405biological_processregulation of penile erection
R0098793cellular_componentpresynapse
R0098921biological_processretrograde trans-synaptic signaling by endocannabinoid
R0098978cellular_componentglutamatergic synapse
R0098982cellular_componentGABA-ergic synapse
R0099509biological_processregulation of presynaptic cytosolic calcium ion concentration
R0099553biological_processtrans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVgSLFLTAIDRYIsI
ChainResidueDetails
RALA202-ILE218

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues154
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RMET1-GLN116
RASP176-ASN187
RASN256-GLU273
RASP366-THR377

site_idSWS_FT_FI2
Number of Residues25
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RLEU117-LEU142
ALEU176
ATHR182
ASER327

site_idSWS_FT_FI3
Number of Residues146
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RHIS143-HIS154
RASP213-LYS232
RLYS300-THR344
RARG400-LEU472

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RPHE155-ILE175

site_idSWS_FT_FI5
Number of Residues24
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RVAL188-ILE212

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RALA233-TRP255

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RTHR274-TRP299

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RLEU345-TYR365

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:27768894, ECO:0000269|PubMed:27851727
ChainResidueDetails
RVAL378-LEU399

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47746
ChainResidueDetails
RSER425
RSER429

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:21895628
ChainResidueDetails
RCYS415

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN77
RASN83

222926

PDB entries from 2024-07-24

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