7X2D

Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-Gs complex

Summary for 7X2D

• Entry DOI: 10.2210/pdb7x2d/pdb
• EMDB information: 32965
• Descriptor: D(1A) dopamine receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• Functional Keywords: gpcr, dopamine receptor, mini-gs, membrane protein, tavapadon
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 146711.00

Authors

Teng, X.,Zheng, S. (deposition date: 2022-02-25, release date: 2022-06-15, Last modification date: 2022-10-12)

• Primary citation: Teng, X.,Chen, S.,Nie, Y.,Xiao, P.,Yu, X.,Shao, Z.,Zheng, S.; Ligand recognition and biased agonism of the D1 dopamine receptor.; Nat Commun, 13:3186-3186, 2022; PubMed: 35676276; DOI: 10.1038/s41467-022-30929-w

Experimental method

ELECTRON MICROSCOPY (3.3 Å)