7FEE

Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1

Summary for 7FEE

Entry DOI	10.2210/pdb7fee/pdb
Descriptor	Cannabinoid receptor 1,GlgA glycogen synthase, CHOLESTEROL, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, ... (9 entities in total)
Functional Keywords	signal protein, membrane protein, gpcr
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	67500.21
Authors	Wang, X.,Zhao, C.,Shao, Z. (deposition date: 2021-07-19, release date: 2022-06-15, Last modification date: 2024-04-03)
Primary citation	Yang, X.,Wang, X.,Xu, Z.,Wu, C.,Zhou, Y.,Wang, Y.,Lin, G.,Li, K.,Wu, M.,Xia, A.,Liu, J.,Cheng, L.,Zou, J.,Yan, W.,Shao, Z.,Yang, S. Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nat.Chem.Biol., 18:831-840, 2022 Cited by PubMed: 35637350 DOI: 10.1038/s41589-022-01038-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation