7V68

An Agonist and PAM-bound Class A GPCR with Gi protein complex structure

Summary for 7V68

• Entry DOI: 10.2210/pdb7v68/pdb
• EMDB information: 31738 31739 31740
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: m4r-gi complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 153181.17

Authors

Wang, J.J.,Wu, L.J.,Wu, M.,Hua, T.,Liu, Z.J.,Wang, T. (deposition date: 2021-08-20, release date: 2022-05-11, Last modification date: 2022-11-23)

• Primary citation: Wang, J.,Wu, M.,Chen, Z.,Wu, L.,Wang, T.,Cao, D.,Wang, H.,Liu, S.,Xu, Y.,Li, F.,Liu, J.,Chen, N.,Zhao, S.,Cheng, J.,Wang, S.,Hua, T.; The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands.; Nat Commun, 13:2855-2855, 2022; PubMed: 35606397; DOI: 10.1038/s41467-022-30595-y

Experimental method

ELECTRON MICROSCOPY (3.4 Å)