7V68
An Agonist and PAM-bound Class A GPCR with Gi protein complex structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 356 | 40559.2 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 4 | S | scFv16 | polymer | 259 | 27784.9 | 1 | Homo sapiens | ||
| 5 | R | Muscarinic acetylcholine receptor M4 | polymer | 346 | 39055.0 | 1 | UniProt (P08173) Pfam (PF00001) In PDB | Homo sapiens (human) | |
| 6 | R | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium | non-polymer | 197.3 | 1 | Chemie (IXO) | |||
| 7 | R | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide | non-polymer | 437.9 | 1 | Chemie (2CU) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
R: 1 - 479 (UniProt: P08173)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| - | Lys 240 | deletion |
| - | Thr 241 | deletion |
| - | Leu 242 | deletion |
| - | Ala 243 | deletion |
| - | Phe 244 | deletion |
| - | Leu 245 | deletion |
| - | Lys 246 | deletion |
| - | Ser 247 | deletion |
| - | Pro 248 | deletion |
| - | Leu 249 | deletion |
| - | Met 250 | deletion |
| - | Lys 251 | deletion |
| - | Gln 252 | deletion |
| - | Ser 253 | deletion |
| - | Val 254 | deletion |
| - | Lys 255 | deletion |
| - | Lys 256 | deletion |
| - | Pro 257 | deletion |
| - | Pro 258 | deletion |
| - | Pro 259 | deletion |
| - | Gly 260 | deletion |
| - | Glu 261 | deletion |
| - | Ala 262 | deletion |
| - | Ala 263 | deletion |
| - | Arg 264 | deletion |
| - | Glu 265 | deletion |
| - | Glu 266 | deletion |
| - | Leu 267 | deletion |
| - | Arg 268 | deletion |
| - | Asn 269 | deletion |
| - | Gly 270 | deletion |
| - | Lys 271 | deletion |
| - | Leu 272 | deletion |
| - | Glu 273 | deletion |
| - | Glu 274 | deletion |
| - | Ala 275 | deletion |
| - | Pro 276 | deletion |
| - | Pro 277 | deletion |
| - | Pro 278 | deletion |
| - | Ala 279 | deletion |
| - | Leu 280 | deletion |
| - | Pro 281 | deletion |
| - | Pro 282 | deletion |
| - | Pro 283 | deletion |
| - | Pro 284 | deletion |
| - | Arg 285 | deletion |
| - | Pro 286 | deletion |
| - | Val 287 | deletion |
| - | Ala 288 | deletion |
| - | Asp 289 | deletion |
| - | Lys 290 | deletion |
| - | Asp 291 | deletion |
| - | Thr 292 | deletion |
| - | Ser 293 | deletion |
| - | Asn 294 | deletion |
| - | Glu 295 | deletion |
| - | Ser 296 | deletion |
| - | Ser 297 | deletion |
| - | Ser 298 | deletion |
| - | Gly 299 | deletion |
| - | Ser 300 | deletion |
| - | Ala 301 | deletion |
| - | Thr 302 | deletion |
| - | Gln 303 | deletion |
| - | Asn 304 | deletion |
| - | Thr 305 | deletion |
| - | Lys 306 | deletion |
| - | Glu 307 | deletion |
| - | Arg 308 | deletion |
| - | Pro 309 | deletion |
| - | Ala 310 | deletion |
| - | Thr 311 | deletion |
| - | Glu 312 | deletion |
| - | Leu 313 | deletion |
| - | Ser 314 | deletion |
| - | Thr 315 | deletion |
| - | Thr 316 | deletion |
| - | Glu 317 | deletion |
| - | Ala 318 | deletion |
| - | Thr 319 | deletion |
| - | Thr 320 | deletion |
| - | Pro 321 | deletion |
| - | Ala 322 | deletion |
| - | Met 323 | deletion |
| - | Pro 324 | deletion |
| - | Ala 325 | deletion |
| - | Pro 326 | deletion |
| - | Pro 327 | deletion |
| - | Leu 328 | deletion |
| - | Gln 329 | deletion |
| - | Pro 330 | deletion |
| - | Arg 331 | deletion |
| - | Ala 332 | deletion |
| - | Leu 333 | deletion |
| - | Asn 334 | deletion |
| - | Pro 335 | deletion |
| - | Ala 336 | deletion |
| - | Ser 337 | deletion |
| - | Arg 338 | deletion |
| - | Trp 339 | deletion |
| - | Ser 340 | deletion |
| - | Lys 341 | deletion |
| - | Ile 342 | deletion |
| - | Gln 343 | deletion |
| - | Ile 344 | deletion |
| - | Val 345 | deletion |
| - | Thr 346 | deletion |
| - | Lys 347 | deletion |
| - | Gln 348 | deletion |
| - | Thr 349 | deletion |
| - | Gly 350 | deletion |
| - | Asn 351 | deletion |
| - | Glu 352 | deletion |
| - | Cys 353 | deletion |
| - | Val 354 | deletion |
| - | Thr 355 | deletion |
| - | Ala 356 | deletion |
| - | Ile 357 | deletion |
| - | Glu 358 | deletion |
| - | Ile 359 | deletion |
| - | Val 360 | deletion |
| - | Pro 361 | deletion |
| - | Ala 362 | deletion |
| - | Thr 363 | deletion |
| - | Pro 364 | deletion |
| - | Ala 365 | deletion |
| - | Gly 366 | deletion |
| - | Met 367 | deletion |
| - | Arg 368 | deletion |
| - | Pro 369 | deletion |
| - | Ala 370 | deletion |
| - | Ala 371 | deletion |
| - | Asn 372 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 152546.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 635.2 | |
| All* | Total formula weight | 153181.2 |
