7WIC

Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex

Summary for 7WIC

• Entry DOI: 10.2210/pdb7wic/pdb
• EMDB information: 32528
• Related PRD ID: PRD_001216
• Descriptor: somatostatin-14, Somatostatin receptor type 2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total)
• Functional Keywords: somatostatin receptor, somatostatin-14, l-054, 264, sstr2, class a gpcr, biosynthetic protein, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 157883.06

Authors

Chen, L.,Wang, W.,Dong, Y.,Shen, D.,Guo, J.,Qin, J.,Zhang, H.,Shen, Q.,Zhang, Y.,Mao, C. (deposition date: 2022-01-03, release date: 2022-06-01, Last modification date: 2022-08-17)

• Primary citation: Chen, L.N.,Wang, W.W.,Dong, Y.J.,Shen, D.D.,Guo, J.,Yu, X.,Qin, J.,Ji, S.Y.,Zhang, H.,Shen, Q.,He, Q.,Yang, B.,Zhang, Y.,Li, Q.,Mao, C.; Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.; Cell Res., 32:785-788, 2022; PubMed: 35578016; DOI: 10.1038/s41422-022-00669-z

Experimental method

ELECTRON MICROSCOPY (2.8 Å)