7SUS
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![BU of 7sus by Molmil](/molmil-images/mine/7sus) | Crystal structure of Apelin receptor in complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Han, G.W, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7Y13
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![BU of 7y13 by Molmil](/molmil-images/mine/7y13) | Cryo-EM structure of apo-state MrgD-Gi complex (local) | 分子名称: | PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7Y12
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![BU of 7y12 by Molmil](/molmil-images/mine/7y12) | Cryo-EM structure of MrgD-Gi complex with beta-alanine | 分子名称: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7Y14
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![BU of 7y14 by Molmil](/molmil-images/mine/7y14) | Cryo-EM structure of MrgD-Gi complex with beta-alanine (local) | 分子名称: | BETA-ALANINE, PALMITIC ACID, Soluble cytochrome b562,Mas-related G-protein coupled receptor member D | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7Y15
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![BU of 7y15 by Molmil](/molmil-images/mine/7y15) | Cryo-EM structure of apo-state MrgD-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | 登録日 | 2022-06-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol, 5, 2022
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7UM7
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![BU of 7um7 by Molmil](/molmil-images/mine/7um7) | CryoEM structure of Go-coupled 5-HT5AR in complex with Methylergometrine | 分子名称: | (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM5
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![BU of 7um5 by Molmil](/molmil-images/mine/7um5) | CryoEM structure of Go-coupled 5-HT5AR in complex with 5-CT | 分子名称: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7UM4
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7UM6
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![BU of 7um6 by Molmil](/molmil-images/mine/7um6) | CryoEM structure of Go-coupled 5-HT5AR in complex with Lisuride | 分子名称: | 5-hydroxytryptamine receptor 5A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, S, Fay, J.F, Roth, B.L. | 登録日 | 2022-04-06 | 公開日 | 2022-07-20 | 最終更新日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nat.Struct.Mol.Biol., 29, 2022
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7XOW
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![BU of 7xow by Molmil](/molmil-images/mine/7xow) | Structural insights into human brain gut peptide cholecystokinin receptors | 分子名称: | Gastrin, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | 登録日 | 2022-05-01 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
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7XOV
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![BU of 7xov by Molmil](/molmil-images/mine/7xov) | Structural insights into human brain gut peptide cholecystokinin receptors | 分子名称: | 2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | 登録日 | 2022-05-01 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
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7XOU
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![BU of 7xou by Molmil](/molmil-images/mine/7xou) | Structural insights into human brain gut peptide cholecystokinin receptors | 分子名称: | CCK-8, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S. | 登録日 | 2022-05-01 | 公開日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural insights into human brain-gut peptide cholecystokinin receptors. Cell Discov, 8, 2022
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7XBD
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![BU of 7xbd by Molmil](/molmil-images/mine/7xbd) | Cryo-EM structure of human galanin receptor 2 | 分子名称: | Galanin, Galanin receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ishimoto, N, Kita, S, Park, S.Y. | 登録日 | 2022-03-21 | 公開日 | 2022-07-13 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface. Plos Biol., 20, 2022
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7XBW
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![BU of 7xbw by Molmil](/molmil-images/mine/7xbw) | Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1 | 分子名称: | CHOLESTEROL, CX3C chemokine receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2022-03-22 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7XBX
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![BU of 7xbx by Molmil](/molmil-images/mine/7xbx) | Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2022-03-22 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7WJ5
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![BU of 7wj5 by Molmil](/molmil-images/mine/7wj5) | Cryo-EM structure of human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand binding specificity | 分子名称: | Gai1 antibody (scfv16), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Heo, Y.S, Yoon, E.J, Jeon, Y.E, Yun, J.-H, Ishimoto, N, Woo, H, Park, S.Y, Song, J, Lee, W.T. | 登録日 | 2022-01-05 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity. Elife, 11, 2022
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7RAN
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![BU of 7ran by Molmil](/molmil-images/mine/7ran) | 5-HT2AR bound to a novel agonist in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | 分子名称: | (3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium, 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2021-07-02 | 公開日 | 2022-07-06 | 最終更新日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature, 610, 2022
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7XTQ
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![BU of 7xtq by Molmil](/molmil-images/mine/7xtq) | Cryo-EM structure of the R399-bound GPBAR-Gs complex | 分子名称: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | 登録日 | 2022-05-17 | 公開日 | 2022-07-06 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UL5
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7UL3
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![BU of 7ul3 by Molmil](/molmil-images/mine/7ul3) | CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab | 分子名称: | Histamine H2 receptor, NabFab HC, NabFab LC, ... | 著者 | Robertson, M.J, Skiniotis, G. | 登録日 | 2022-04-03 | 公開日 | 2022-06-29 | 最終更新日 | 2022-12-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure determination of inactive-state GPCRs with a universal nanobody. Nat.Struct.Mol.Biol., 29, 2022
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7UL2
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7UL4
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7XJL
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![BU of 7xjl by Molmil](/molmil-images/mine/7xjl) | Cryo-EM structure of the spexin-bound GALR2-miniGq complex | 分子名称: | Galanin receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jiang, W, Zheng, S. | 登録日 | 2022-04-18 | 公開日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into galanin receptor signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XJK
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7X2C
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![BU of 7x2c by Molmil](/molmil-images/mine/7x2c) | Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-Gs complex | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Teng, X, Zheng, S. | 登録日 | 2022-02-25 | 公開日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun, 13, 2022
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