7SUS

Crystal structure of Apelin receptor in complex with small molecule

Summary for 7SUS

• Entry DOI: 10.2210/pdb7sus/pdb
• Descriptor: Apelin receptor, with Rubredoxin insertion, ZINC ION, (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, ... (5 entities in total)
• Functional Keywords: gpcr, class a gpcr, small molecule, membrane protein, apelin receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 47384.14

Authors

Xu, F.,Yue, Y.,Liu, L.E.,Han, G.W.,Hanson, M. (deposition date: 2021-11-18, release date: 2022-07-27, Last modification date: 2023-10-18)

• Primary citation: Yue, Y.,Liu, L.,Wu, L.J.,Wu, Y.,Wang, L.,Li, F.,Liu, J.,Han, G.W.,Chen, B.,Lin, X.,Brouillette, R.L.,Breault, E.,Longpre, J.M.,Shi, S.,Lei, H.,Sarret, P.,Stevens, R.C.,Hanson, M.A.,Xu, F.; Structural insight into apelin receptor-G protein stoichiometry.; Nat.Struct.Mol.Biol., 29:688-697, 2022; PubMed: 35817871; DOI: 10.1038/s41594-022-00797-5

Experimental method

X-RAY DIFFRACTION (2.7 Å)