7XBD

Cryo-EM structure of human galanin receptor 2

Summary for 7XBD

Entry DOI	10.2210/pdb7xbd/pdb
EMDB information	33103
Descriptor	Galanin receptor type 2, Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywords	gpcr, membrane protein, galanin
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	145743.01
Authors	Ishimoto, N.,Kita, S.,Park, S.Y. (deposition date: 2022-03-21, release date: 2022-07-13, Last modification date: 2022-08-10)
Primary citation	Heo, Y.,Ishimoto, N.,Jeon, Y.E.,Yun, J.H.,Ohki, M.,Anraku, Y.,Sasaki, M.,Kita, S.,Fukuhara, H.,Ikuta, T.,Kawakami, K.,Inoue, A.,Maenaka, K.,Tame, J.R.H.,Lee, W.,Park, S.Y. Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface. Plos Biol., 20:e3001714-e3001714, 2022 Cited by PubMed: 35913979 DOI: 10.1371/journal.pbio.3001714 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.11 Å)

Structure validation