7UL4

CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6

Summary for 7UL4

• Entry DOI: 10.2210/pdb7ul4/pdb
• EMDB information: 26591
• Descriptor: Mu-type opioid receptor, Megabody 6, N-[(2S)-2-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine, ... (4 entities in total)
• Functional Keywords: antagonist, complex, membrane protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 104007.35

Authors

Robertson, M.J.,Skiniotis, G. (deposition date: 2022-04-03, release date: 2022-06-29, Last modification date: 2022-12-28)

• Primary citation: Robertson, M.J.,Papasergi-Scott, M.M.,He, F.,Seven, A.B.,Meyerowitz, J.G.,Panova, O.,Peroto, M.C.,Che, T.,Skiniotis, G.; Structure determination of inactive-state GPCRs with a universal nanobody.; Nat.Struct.Mol.Biol., 29:1188-1195, 2022; PubMed: 36396979; DOI: 10.1038/s41594-022-00859-8

Experimental method

ELECTRON MICROSCOPY (2.8 Å)