7UL4
CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001965 | molecular_function | G-protein alpha-subunit binding |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004979 | molecular_function | beta-endorphin receptor activity |
| A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| A | 0007197 | biological_process | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway |
| A | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| A | 0007218 | biological_process | neuropeptide signaling pathway |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0016020 | cellular_component | membrane |
| A | 0016529 | cellular_component | sarcoplasmic reticulum |
| A | 0019226 | biological_process | transmission of nerve impulse |
| A | 0019233 | biological_process | sensory perception of pain |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030315 | cellular_component | T-tubule |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0031635 | biological_process | adenylate cyclase-inhibiting opioid receptor signaling pathway |
| A | 0031681 | molecular_function | G-protein beta-subunit binding |
| A | 0032100 | biological_process | positive regulation of appetite |
| A | 0032590 | cellular_component | dendrite membrane |
| A | 0032839 | cellular_component | dendrite cytoplasm |
| A | 0033685 | biological_process | negative regulation of luteinizing hormone secretion |
| A | 0035176 | biological_process | social behavior |
| A | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
| A | 0038047 | molecular_function | morphine receptor activity |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042713 | biological_process | sperm ejaculation |
| A | 0042734 | cellular_component | presynaptic membrane |
| A | 0042755 | biological_process | eating behavior |
| A | 0042923 | molecular_function | neuropeptide binding |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043204 | cellular_component | perikaryon |
| A | 0045019 | biological_process | negative regulation of nitric oxide biosynthetic process |
| A | 0045211 | cellular_component | postsynaptic membrane |
| A | 0045471 | biological_process | response to ethanol |
| A | 0045722 | biological_process | positive regulation of gluconeogenesis |
| A | 0048149 | biological_process | behavioral response to ethanol |
| A | 0050769 | biological_process | positive regulation of neurogenesis |
| A | 0051481 | biological_process | negative regulation of cytosolic calcium ion concentration |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0061358 | biological_process | negative regulation of Wnt protein secretion |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071315 | biological_process | cellular response to morphine |
| A | 0080135 | biological_process | regulation of cellular response to stress |
| A | 0097444 | cellular_component | spine apparatus |
| A | 0098982 | cellular_component | GABA-ergic synapse |
| A | 0099171 | biological_process | presynaptic modulation of chemical synaptic transmission |
| A | 0106072 | biological_process | negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| A | 2000310 | biological_process | regulation of NMDA receptor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIfTLCTMSVDRYIaV |
| Chain | Residue | Details |
| A | THR153-VAL169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 17 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"22437502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Motif: {"description":"NPxxY; plays a role in stabilizing the activated conformation of the receptor","evidences":[{"source":"PubMed","id":"26245379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P33535","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
