7XBW

Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1

Summary for 7XBW

• Entry DOI: 10.2210/pdb7xbw/pdb
• EMDB information: 33107
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, chemokine receptor, cx3cr1, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 128786.73

Authors

Lu, M.,Zhao, W.,Han, S.,Zhu, Y.,Wu, B.,Zhao, Q. (deposition date: 2022-03-22, release date: 2022-07-13)

• Primary citation: Lu, M.,Zhao, W.,Han, S.,Lin, X.,Xu, T.,Tan, Q.,Wang, M.,Yi, C.,Chu, X.,Yang, W.,Zhu, Y.,Wu, B.,Zhao, Q.; Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.; Sci Adv, 8:eabn8048-eabn8048, 2022; PubMed: 35767622; DOI: 10.1126/sciadv.abn8048

Experimental method

ELECTRON MICROSCOPY (2.8 Å)