7UL2

CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6

Summary for 7UL2

• Entry DOI: 10.2210/pdb7ul2/pdb
• EMDB information: 26589
• Descriptor: Neurotensin receptor 1, Nanobody 6, 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid, ... (5 entities in total)
• Functional Keywords: antagonist, complex, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62424.70

Authors

Robertson, M.J.,Skiniotis, G. (deposition date: 2022-04-03, release date: 2022-06-29, Last modification date: 2022-12-28)

• Primary citation: Robertson, M.J.,Papasergi-Scott, M.M.,He, F.,Seven, A.B.,Meyerowitz, J.G.,Panova, O.,Peroto, M.C.,Che, T.,Skiniotis, G.; Structure determination of inactive-state GPCRs with a universal nanobody.; Nat.Struct.Mol.Biol., 29:1188-1195, 2022; PubMed: 36396979; DOI: 10.1038/s41594-022-00859-8

Experimental method

ELECTRON MICROSCOPY (2.4 Å)