7UL2

CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	Neurotensin receptor 1	polymer	419	47084.4	1	UniProt (P30989) UniProt (P41145) Pfam (PF00001)	Homo sapiens (human)	NT-R-1,NTR1,High-affinity levocabastine-insensitive neurotensin receptor,NTRH,K-OR-1,KOR-1
2	B (D)	Nanobody 6	polymer	133	14730.3	1		Lama glama
3	C (R)	2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid	non-polymer		587.1	1	Chemie (Q6Q)
4	D (R)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	E (R)	water	water		18.0	13	Chemie (HOH)

Sequence modifications

R: 20 - 255 (UniProt: P30989)

PDB	External Database	Details
Asp -19	-	expression tag
Tyr -18	-	expression tag
Lys -17	-	expression tag
Asp -16	-	expression tag
Asp -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Ala -12	-	expression tag
Met -11	-	expression tag
Gly -10	-	expression tag
Gln -9	-	expression tag
Pro -8	-	expression tag
Gly -7	-	expression tag
Asn -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
Ala -3	-	expression tag
Phe -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Ala 1	-	expression tag
Pro 2	-	expression tag
Asn 3	-	expression tag
Arg 4	-	expression tag
Ser 5	-	expression tag
His 6	-	expression tag
Ala 7	-	expression tag
Pro 8	-	expression tag
Asp 9	-	expression tag
His 10	-	expression tag
Asp 11	-	expression tag
Val 12	-	expression tag
Glu 13	-	expression tag
Asn 14	-	expression tag
Leu 15	-	expression tag
Tyr 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag
Leu 85	Ala 85	conflict

R: 256 - 308 (UniProt: P41145)

PDB	External Database	Details
Ala 307	Val 278	conflict

R: 309 - 418 (UniProt: P30989)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61814.6
Non-Polymers*	Number of molecules	2
	Total formula weight	610.1
All*	Total formula weight	62424.7

*Water molecules are not included.