7UL2

CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0004930	molecular_function	G protein-coupled receptor activity
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0016020	cellular_component	membrane
R	0016492	molecular_function	G protein-coupled neurotensin receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI

Chain	Residue	Details
R	ALA154-ILE170

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site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. VLytLmIlRlkSvRllsgsrekdrNLrrItrLV

Chain	Residue	Details
R	VAL254-VAL305

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	ALA68-LEU88

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site_id	SWS_FT_FI2
Number of Residues	85
Details	TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	ALA89-HIS102
R	GLU165-ARG184
R	ASN365-TYR418

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site_id	SWS_FT_FI3
Number of Residues	19
Details	TRANSMEM: Helical; Name=2 => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	TYR103-VAL122

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site_id	SWS_FT_FI4
Number of Residues	64
Details	TOPO_DOM: Extracellular => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	GLU123-ARG142
R	THR206-LYS234
R	PHE326-HIS343

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3 => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	GLY143-VAL164

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site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	THR185-PHE205

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site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P20789

Chain	Residue	Details
R	TYR344-TYR364

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site_id	SWS_FT_FI8
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000305|PubMed:21725197

Chain	Residue	Details
R	CYS381
R	CYS383

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
R	ASN37
R	ASN41

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site_id	SWS_FT_FI10
Number of Residues	26
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
R	LEU258-ARG303

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