6KN0
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7PAV
| MALT1 in complex with compound 1 | 分子名称: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ~{N}1,~{N}4-bis[2-(trifluoromethyl)pyrimidin-4-yl]cyclohexane-1,4-diamine | 著者 | Kack, H, Oster, L. | 登録日 | 2021-07-30 | 公開日 | 2021-11-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors. Eur.J.Med.Chem., 227, 2021
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7PAW
| MALT1 in complex with compound 1 | 分子名称: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ~{N}1-(3-chloranyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-~{N}4-[2-(trifluoromethyl)pyrimidin-4-yl]cyclohexane-1,4-diamine | 著者 | Kack, H, Oster, L. | 登録日 | 2021-07-30 | 公開日 | 2021-11-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Discovery and optimization of cyclohexane-1,4-diamines as allosteric MALT1 inhibitors. Eur.J.Med.Chem., 227, 2021
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8V4X
| Structure of MALT1 in complex with an allosteric inhibitor | 分子名称: | Inhibitor peptide, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, N-{7-[(1S)-1-methoxyethyl]-2-methyl[1,3]thiazolo[5,4-b]pyridin-6-yl}-N'-[6-(2H-1,2,3-triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea | 著者 | Judge, R.A, Pappano, W.N. | 登録日 | 2023-11-29 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.486 Å) | 主引用文献 | Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma. Mol.Cancer Ther., 23, 2024
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6YN8
| Human MALT1(334-719) in complex with a tetrazole containing compound | 分子名称: | 3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Renatus, M. | 登録日 | 2020-04-11 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.052 Å) | 主引用文献 | Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3, 2020
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6F7I
| human MALT1(329-728) IN COMPLEX WITH MLT-747 | 分子名称: | 1-[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloranyl-6-pyrrolidin-1-ylcarbonyl-pyridin-3-yl)urea, GLYCEROL, MAGNESIUM ION, ... | 著者 | Renatus, M, Renatus, M. | 登録日 | 2017-12-09 | 公開日 | 2019-01-02 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat. Chem. Biol., 15, 2019
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7A41
| MALT1 in complex with a NVS-MALT1 chemical probe | 分子名称: | DIMETHYL SULFOXIDE, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, ~{N}-[(1~{S})-1-[4-[[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]amino]phenyl]-2,2,2-tris(fluoranyl)ethyl]-~{N}-methyl-1,1-bis(oxidanylidene)thiane-4-carboxamide | 著者 | Renatus, M. | 登録日 | 2020-08-19 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | MALT1 in complex with a NVS-MALT1 chemical probe Not Published
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7AK0
| Human MALT1(329-729) in complex with a chromane urea containing inhibitor | 分子名称: | 1-[4-[4-(aminomethyl)pyrazol-1-yl]-3-chloranyl-phenyl]-3-[(3~{R})-6-bromanyl-3,4-dihydro-2~{H}-chromen-3-yl]urea, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Renatus, M. | 登録日 | 2020-09-29 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.316 Å) | 主引用文献 | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. J.Med.Chem., 63, 2020
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7AK1
| Human MALT1(329-729) in complex with a chromane urea containing inhibitor | 分子名称: | 1-(3-chloranyl-4-methoxy-phenyl)-3-[7-[(3~{S})-3-(methoxymethyl)morpholin-4-yl]-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]urea, MAGNESIUM ION, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Renatus, M. | 登録日 | 2020-09-29 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | 主引用文献 | Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. J.Med.Chem., 63, 2020
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6VIE
| Structure of caspase-1 in complex with gasdermin D | 分子名称: | Caspase-1 subunit p10, Caspase-1 subunit p20, Gasdermin-D | 著者 | Liu, Z, Xiao, T.S. | 登録日 | 2020-01-13 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Immunity, 53, 2020
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6KMZ
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6KMV
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6YN9
| MALT1(329-728) in complex with a sulfonamide containing compound | 分子名称: | 5-[4-[(2,6-diethylphenyl)sulfamoyl]-3-methyl-phenyl]furan-3-carboxylic acid, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 著者 | Renatus, M. | 登録日 | 2020-04-11 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.558 Å) | 主引用文献 | Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3, 2020
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3J9K
| Structure of Dark apoptosome in complex with Dronc CARD domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Apaf-1 related killer DARK, Caspase Nc | 著者 | Pang, Y, Bai, X, Yan, C, Hao, Q, Chen, Z, Wang, J, Scheres, S.H.W, Shi, Y. | 登録日 | 2015-02-04 | 公開日 | 2015-02-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila. Genes Dev., 29, 2015
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7XN4
| Cryo-EM structure of CopC-CaM-caspase-3 with NAD+ | 分子名称: | Arginine ADP-riboxanase CopC, Calmodulin-1, Caspase-3, ... | 著者 | Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S. | 登録日 | 2022-04-28 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol.Cell, 82, 2022
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7XN5
| Cryo-EM structure of CopC-CaM-caspase-3 with ADPR | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Arginine ADP-riboxanase CopC, Calmodulin-1, ... | 著者 | Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S. | 登録日 | 2022-04-28 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.18 Å) | 主引用文献 | Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol.Cell, 82, 2022
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7XN6
| Cryo-EM structure of CopC-CaM-caspase-3 with ADPR-deacylization | 分子名称: | Arginine ADP-riboxanase CopC, Calmodulin-1, Caspase-3, ... | 著者 | Zhang, K, Peng, T, Tao, X.Y, Tian, M, Li, Y.X, Wang, Z, Ma, S.F, Hu, S.F, Pan, X, Xue, J, Luo, J.W, Wu, Q.L, Fu, Y, Li, S. | 登録日 | 2022-04-28 | 公開日 | 2022-12-14 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structural insights into caspase ADPR deacylization catalyzed by a bacterial effector and host calmodulin. Mol.Cell, 82, 2022
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7WR4
| Crystal structure of OspC3-calmodulin-caspase-4 complex | 分子名称: | Calmodulin-1, Caspase-4, OspC3 | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
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7WR6
| Crystal structure of ADP-riboxanated caspase-4 in complex with Af1521 | 分子名称: | ADP-ribose glycohydrolase AF_1521, Caspase-4, [[(3~{a}~{S},5~{R},6~{R},6~{a}~{R})-2-azanylidene-3-[(4~{R})-4-azanyl-5-oxidanylidene-pentyl]-6-oxidanyl-3~{a},5,6,6~{a}-tetrahydrofuro[2,3-d][1,3]oxazol-5-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
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7WR1
| P32 of caspase-4 C258A mutant in complex with OspC3 C-terminal ankyrin-repeat domain | 分子名称: | Caspase-4, OspC3 | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
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7WR5
| Crystal structure of OspC3-calmodulin-caspase-4 complex binding with 2'-aF-NAD+ | 分子名称: | Calmodulin-1, Caspase-4, OspC3, ... | 著者 | Hou, Y.J, Zeng, H, Shao, F, Ding, J. | 登録日 | 2022-01-26 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. Nat.Struct.Mol.Biol., 30, 2023
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7WZS
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1I4E
| CRYSTAL STRUCTURE OF THE CASPASE-8/P35 COMPLEX | 分子名称: | Caspase-8, Early 35 kDa protein | 著者 | Xu, G, Cirilli, M, Huang, Y, Rich, R.L, Myszka, D.G, Wu, H. | 登録日 | 2001-02-20 | 公開日 | 2001-03-28 | 最終更新日 | 2013-09-25 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature, 410, 2001
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3UO8
| Crystal structure of the MALT1 paracaspase (P1 form) | 分子名称: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | 著者 | Jeffrey, P.D, Yu, J.W, Shi, Y. | 登録日 | 2011-11-16 | 公開日 | 2011-12-21 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proc.Natl.Acad.Sci.USA, 108, 2011
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3V4L
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