6KN0

caspase-1 P20/P10 C285A in complex with human GSDMD-C domain

Summary for 6KN0

• Entry DOI: 10.2210/pdb6kn0/pdb
• Descriptor: Caspase-1, Gasdermin-D (3 entities in total)
• Functional Keywords: pyroptosis, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 100575.40

Authors

Ding, J.,Sun, Q. (deposition date: 2019-08-02, release date: 2020-03-11, Last modification date: 2023-11-22)

• Primary citation: Wang, K.,Sun, Q.,Zhong, X.,Zeng, M.,Zeng, H.,Shi, X.,Li, Z.,Wang, Y.,Zhao, Q.,Shao, F.,Ding, J.; Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.; Cell, 180:941-, 2020; PubMed: 32109412; DOI: 10.1016/j.cell.2020.02.002

Experimental method

X-RAY DIFFRACTION (2.793 Å)