6KN0

caspase-1 P20/P10 C285A in complex with human GSDMD-C domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HktsdStfLvFMSHG

Chain	Residue	Details
A	HIS224-GLY238

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"1574116","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"1574116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32051255","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"30065070","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Cleavage; by papain","evidences":[{"source":"PubMed","id":"35794369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"32820063","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 718

Chain	Residue	Details
B	GLU390	electrostatic stabiliser
A	GLY238	electrostatic stabiliser
A	ALA285	nucleofuge, nucleophile, proton acceptor, proton donor
A	ARG286	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	1
Details	M-CSA 718

Chain	Residue	Details
D	GLU390	electrostatic stabiliser
C	GLY238	electrostatic stabiliser
C	ALA285	nucleofuge, nucleophile, proton acceptor, proton donor
C	ARG286	electrostatic stabiliser

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