6F7I

human MALT1(329-728) IN COMPLEX WITH MLT-747

Summary for 6F7I

Entry DOI	10.2210/pdb6f7i/pdb
Descriptor	Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 1-[2-chloranyl-7-[(1~{S})-1-methoxyethyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-(5-chloranyl-6-pyrrolidin-1-ylcarbonyl-pyridin-3-yl)urea, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	dimer, exosite binder, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	92548.23
Authors	Renatus, M.,Renatus, M. (deposition date: 2017-12-09, release date: 2019-01-02, Last modification date: 2024-05-01)
Primary citation	Quancard, J.,Klein, T.,Fung, S.Y.,Renatus, M.,Hughes, N.,Israel, L.,Priatel, J.J.,Kang, S.,Blank, M.A.,Viner, R.I.,Blank, J.,Schlapbach, A.,Erbel, P.,Kizhakkedathu, J.,Villard, F.,Hersperger, R.,Turvey, S.E.,Eder, J.,Bornancin, F.,Overall, C.M. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat. Chem. Biol., 15:304-313, 2019 Cited by PubMed: 30692685 DOI: 10.1038/s41589-018-0222-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation