6YN8

Human MALT1(334-719) in complex with a tetrazole containing compound

Summary for 6YN8

• Entry DOI: 10.2210/pdb6yn8/pdb
• Descriptor: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide (3 entities in total)
• Functional Keywords: dimer, active site inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 44495.09

Authors

Renatus, M. (deposition date: 2020-04-11, release date: 2020-06-24, Last modification date: 2024-01-24)

• Primary citation: Hughes, N.,Erbel, P.,Bornancin, F.,Wiesmann, C.,Schiering, N.,Villard, F.,Decock, A.,Rubi, B.,Melkko, S.,Spanka, C.,Buschmann, N.,Pissot-Soldermann, C.,Simic, O.,Beerli, R.,Sorge, M.,Tintelnot-Blomley, M.,Beltz, K.,Regnier, C.H.,Quancard, J.,Schlapbach, A.,Langlois, J.,Renatus, M.; Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity; Advanced Therapeutics, 3:-, 2020; DOI: 10.1002/adtp.202000078

Experimental method

X-RAY DIFFRACTION (3.052 Å)