6YN8
Human MALT1(334-719) in complex with a tetrazole containing compound
Summary for 6YN8
Entry DOI | 10.2210/pdb6yn8/pdb |
Descriptor | Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide (3 entities in total) |
Functional Keywords | dimer, active site inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 44495.09 |
Authors | Renatus, M. (deposition date: 2020-04-11, release date: 2020-06-24, Last modification date: 2024-01-24) |
Primary citation | Hughes, N.,Erbel, P.,Bornancin, F.,Wiesmann, C.,Schiering, N.,Villard, F.,Decock, A.,Rubi, B.,Melkko, S.,Spanka, C.,Buschmann, N.,Pissot-Soldermann, C.,Simic, O.,Beerli, R.,Sorge, M.,Tintelnot-Blomley, M.,Beltz, K.,Regnier, C.H.,Quancard, J.,Schlapbach, A.,Langlois, J.,Renatus, M. Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity Advanced Therapeutics, 3:-, 2020 Cited by DOI: 10.1002/adtp.202000078PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.052 Å) |
Structure validation
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