8V4X

Structure of MALT1 in complex with an allosteric inhibitor

This is a non-PDB format compatible entry.

Summary for 8V4X

• Entry DOI: 10.2210/pdb8v4x/pdb
• Related PRD ID: PRD_001076
• Descriptor: Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Inhibitor peptide, N-{7-[(1S)-1-methoxyethyl]-2-methyl[1,3]thiazolo[5,4-b]pyridin-6-yl}-N'-[6-(2H-1,2,3-triazol-2-yl)-5-(trifluoromethyl)pyridin-3-yl]urea, ... (4 entities in total)
• Functional Keywords: hydrolase, allosteric inhibitor., hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 269253.47

Authors

Judge, R.A.,Pappano, W.N. (deposition date: 2023-11-29, release date: 2024-05-01)

• Primary citation: Plotnik, J.P.,Richardson, A.E.,Yang, H.,Rojas, E.,Bontcheva, V.,Dowell, C.,Parsons, S.,Wilson, A.,Ravanmehr, V.,Will, C.,Jung, P.,Zhu, H.,Partha, S.K.,Panchal, S.C.,Mali, R.S.,Kohlhapp, F.J.,McClure, R.A.,Ramathal, C.Y.,George, M.D.,Jhala, M.,Elsen, N.L.,Qiu, W.,Judge, R.A.,Pan, C.,Mastracchio, A.,Henderson, J.,Meulbroek, J.A.,Green, M.R.,Pappano, W.N.; Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.; Mol.Cancer Ther., 2024; PubMed: 38507740; DOI: 10.1158/1535-7163.MCT-23-0518

Experimental method

X-RAY DIFFRACTION (2.486 Å)