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PDB: 162 件
7WQ4
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Galanin-bound galanin receptor 2 in complex with Gq
分子名称: CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ...
著者Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
登録日2022-01-24
公開日2022-04-20
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
7PWD
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Structure of an inhibited GRK2-G-beta and G-gamma complex
分子名称: 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide, Beta-adrenergic receptor kinase 1, CHLORIDE ION, ...
著者Faucher, N, Tauchert, M.J, Konz Makino, D.L, Vuillard, L.M.
登録日2021-10-06
公開日2021-10-20
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors
Monatsh Chem, 2022
8HA0
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Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhao, L, Xu, H.E, Yuan, Q.
登録日2022-10-26
公開日2022-12-21
最終更新日2023-05-31
実験手法ELECTRON MICROSCOPY (2.62 Å)
主引用文献Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1.
Acta Pharmacol.Sin., 44, 2023
3PSC
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Bovine GRK2 in complex with Gbetagamma subunits
分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
著者Thal, D.M, Tesmer, J.J.
登録日2010-12-01
公開日2011-06-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
8YKX
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Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid
分子名称: Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E.
登録日2024-03-05
公開日2024-05-29
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.69 Å)
主引用文献Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 2024
1XHM
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The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1, SIGK Peptide
著者Davis, T.L, Bonacci, T.M, Smrcka, A.V, Sprang, S.R.
登録日2004-09-20
公開日2005-08-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Molecular Characterization of a Preferred Protein Interaction Surface on G Protein betagamma Subunits.
Biochemistry, 44, 2005
7WIG
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Cryo-EM structure of the L-054,264-bound human SSTR2-Gi1 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C.
登録日2022-01-03
公開日2022-06-01
最終更新日2022-08-17
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes.
Cell Res., 32, 2022
7WQ3
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Galanin-bound galanin receptor 1 in complex with Gi
分子名称: CHOLESTEROL, Galanin, Galanin receptor type 1, ...
著者Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
登録日2022-01-24
公開日2022-04-20
最終更新日2022-10-19
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Nat Commun, 13, 2022
7XWO
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Neurokinin A bound to active human neurokinin 2 receptor in complex with G324
分子名称: G324, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Sun, W.J, Yuan, Q.N, Zhang, H.H, Yang, F, Ling, S.L, Lv, P, Eric, X, Tian, C.L, Yin, W.C, Shi, P.
登録日2022-05-26
公開日2023-05-31
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural insights into the activation of neurokinin 2 receptor by neurokinin A.
Cell Discov, 8, 2022
7XW9
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Cryo-EM structure of the TRH-bound human TRHR-Gq complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y.
登録日2022-05-26
公開日2022-12-28
最終更新日2024-01-10
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Cell Discov, 8, 2022
8WG8
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Cryo-EM structures of peptide free and Gs-coupled GCGR
分子名称: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W.
登録日2023-09-20
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (2.71 Å)
主引用文献Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins.
Cell Discov, 10, 2024
8WZ2
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Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
分子名称: G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Jin, S, Li, X, Xu, Y, Guo, S, Wu, C, Zhang, H, Yuan, Q, Xu, H.E, Xie, X, Jiang, Y.
登録日2023-11-01
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (2.73 Å)
主引用文献Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor.
Cell Discov, 10, 2024
8INR
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Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex
分子名称: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ...
著者Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W.
登録日2023-03-10
公開日2023-09-20
実験手法ELECTRON MICROSCOPY (2.73 Å)
主引用文献Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors.
Cell Discov, 9, 2023
7VQX
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BU of 7vqx by Molmil
Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W.
登録日2021-10-21
公開日2022-05-18
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2.
Nat Commun, 13, 2022
6C2Y
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Human GRK2 in complex with Gbetagamma subunits and CCG257142
分子名称: (4R,5R,6S)-4-[4-fluoro-3-({[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}carbamoyl)phenyl]-N-(2H-indazol-5-yl)-6-methyl-2-oxohexahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Bouley, R, Tesmer, J.J.G.
登録日2018-01-09
公開日2018-04-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
8YKW
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Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid
分子名称: Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E.
登録日2024-03-05
公開日2024-05-29
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 2024
7YK7
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Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ...
著者Chen, Y, Zhou, Q.T, Wang, J, Xu, Y.W, Wang, Y, Yan, J.H, Wang, Y.B, Zhu, Q, Zhao, F.H, Li, C.H, Chen, C.W, Cai, X.Q, Bathgate, R.A.D, Shen, C, Xu, H.E, Yang, D.H, Liu, H, Wang, M.W.
登録日2022-07-21
公開日2023-03-01
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Nat Commun, 14, 2023
3CIK
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Human GRK2 in Complex with Gbetagamma subunits
分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Tesmer, J.J.G, Lodowski, D.T.
登録日2008-03-11
公開日2009-02-17
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
8JIU
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Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex
分子名称: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T.
登録日2023-05-27
公開日2023-09-13
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structural analysis of the dual agonism at GLP-1R and GCGR.
Proc.Natl.Acad.Sci.USA, 120, 2023
8IY5
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ETB-Gi complex bound to endothelin-1
分子名称: Endothelin type B receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Sano, F.K, Akasaka, H, Shihoya, W, Nureki, O.
登録日2023-04-04
公開日2023-08-16
最終更新日2023-12-06
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-EM structure of the endothelin-1-ET B -G i complex.
Elife, 12, 2023
8JBG
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Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein Gq (G324), ...
著者Sun, W.J, Yang, F, Zhang, H.H, Yuan, Q.N, Yin, W.C, Shi, P, Eric, X, Tian, C.L.
登録日2023-05-08
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists.
Cell Discov, 9, 2023
7F16
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Cryo-EM structure of parathyroid hormone receptor type 2 in complex with a tuberoinfundibular peptide of 39 residues and G protein
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Wang, X, Cheng, X, Zhao, L.H, Wang, Y, Ye, C, Zou, X, Dai, A, Cong, Z, Chen, J, Zhou, Q, Xia, T, Jiang, H, Xu, H.E, Yang, D, Wang, M.W.
登録日2021-06-08
公開日2021-08-18
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2.
Proc.Natl.Acad.Sci.USA, 118, 2021
8EFO
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PZM21-bound mu-opioid receptor-Gi complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E.
登録日2022-09-08
公開日2022-11-09
最終更新日2022-11-30
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.
Cell, 185, 2022
7VVL
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PTH-bound human PTH1R in complex with Gs (class2)
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Kobayashi, K, Kusakizako, T, Miyauchi, H, Tomita, A, Kobayashi, K, Shihoya, W, Yamashita, K, Nishizawa, T, Kato, H.E, Nureki, O.
登録日2021-11-06
公開日2022-08-03
最終更新日2023-02-15
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Endogenous ligand recognition and structural transition of a human PTH receptor.
Mol.Cell, 82, 2022
7Y36
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Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ...
著者Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z.
登録日2022-06-10
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published

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件を2024-07-17に公開中

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