6C2Y

Human GRK2 in complex with Gbetagamma subunits and CCG257142

Summary for 6C2Y

Entry DOI	10.2210/pdb6c2y/pdb
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
Functional Keywords	transferase-signaling protein complex, transferase/signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	126304.04
Authors	Bouley, R.,Tesmer, J.J.G. (deposition date: 2018-01-09, release date: 2018-04-25, Last modification date: 2023-10-04)
Primary citation	Waldschmidt, H.V.,Bouley, R.,Kirchhoff, P.D.,Lee, P.,Tesmer, J.J.G.,Larsen, S.D. Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors. Bioorg. Med. Chem. Lett., 28:1507-1515, 2018 Cited by PubMed: 29627263 DOI: 10.1016/j.bmcl.2018.03.082 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.74 Å)

Structure validation